Rejuran vs Juvelook vs Chanel: Skin Boosters in Korea

💡 Quick Summary: At a Glance

Rejuran is a regenerative treatment that restores a damaged skin barrier, with the most pain and downtime of the three.
Juvelook stimulates collagen production to improve pores and acne scars, with effects building over 4–8 weeks.
NCTF 135HA (the "Chanel injection," 샤넬주사) delivers immediate hydration and glow with the shortest downtime.
Always disclose allergies, pregnancy, breastfeeding, and current medications during your consultation before treatment.

🎯 Who This Guide Is For: Anyone researching skin booster treatments in Korea ahead of a wedding, photoshoot, or other important event, and trying to understand the differences between these treatments, how they can be combined, and what timeline to plan before booking a consultation.

Rejuran, Juvelook, and the Chanel Injection — What's the Difference

Three popular Korean skin boosters, compared at a glance.

Rejuran, Juvelook, and NCTF 135HA (often called the "Chanel injection," 샤넬주사) are the three most commonly performed skin boosters at Korean dermatology clinics. A skin booster is a general term for treatments that inject substances into the deeper layers of the skin to stimulate collagen production or deliver hydration.

Rejuran uses polynucleotides (PN, a salmon-derived ingredient that helps damaged tissue recover) to focus on regenerating a damaged skin barrier, with effects beginning to appear within 1–2 weeks after treatment. Juvelook combines PDLLA (poly-D,L-lactic acid, a biodegradable polymer that stimulates collagen production) with hyaluronic acid to improve enlarged pores, acne scars, and loss of elasticity; noticeable changes are felt starting around 2–4 weeks after treatment, with full effects taking 4–8 weeks. NCTF 135HA is a product that adds around 50 types of vitamins, minerals, and amino acids to non-crosslinked hyaluronic acid, quickly boosting hydration and glow within 3–7 days, and it also has the shortest downtime of the three treatments.

Which treatment is right for you depends on how much time you have before your event and your primary skin concern.

Quick Comparison

Category	Rejuran Healer	Juvelook	NCTF 135HA (Chanel Injection)
Key ingredient	Polynucleotides (PN)	PDLLA + hyaluronic acid	Non-crosslinked HA + vitamins/minerals/amino acids
Main purpose	Cell regeneration, barrier repair	Collagen production, pore/scar improvement	Cell nourishment, immediate glow
Onset of effects	1–2 weeks	Noticeable effects in 2–4 weeks, full effects in 4–8 weeks	3–7 days
Pain/downtime	High pain, 2–3 days swelling (embossing)	Moderate pain, swelling about 24 hours	Low pain, downtime under 1 day

⚠️ Disclose Before Treatment

If you have allergies (especially fish allergies), are pregnant or breastfeeding, or are taking any medications, you must disclose this during the consultation before treatment. See the "Considerations" section below for details.

Who This Article Is For

This article is for anyone researching skin booster treatments in Korea ahead of a wedding, photoshoot, or other important event. It's meant to help you understand the differences between the three treatments, how they can be combined, and roughly what timeline to expect before booking a consultation. This article cannot replace an in-person treatment, and your final choice should be made in consultation with a board-certified dermatologist.

👉 Curious what other dermatology treatments are available at trusted clinics in Korea? Browse dermatology treatments at SafeDoc partner hospitals

3 Skin Concerns Skin Boosters Address

Each treatment targets a different underlying skin concern.

Each of the three treatments targets a different skin concern. Figuring out which one matches your concern first makes comparing them much easier.

Weakened Barrier

When the skin barrier (a brick-like structure that prevents moisture loss and blocks external irritants) thins out, redness, sensitivity, and fine lines become more noticeable. This applies to cases where the barrier has been weakened by UV exposure, stress, or repeated procedures.

Collagen Loss

Collagen (the structural protein that supports the skin) naturally declines with age. This leads to enlarged pores, more visible acne scars, and reduced elasticity.

Dullness and Dehydration

When skin cells lack nourishment, skin tone becomes dull and surface moisture evaporates quickly. This is more a matter of overall condition than structural damage.

A Closer Look at Each Treatment

Rejuran Healer: Barrier Regeneration

If you have a history of allergic reactions to salmon-derived ingredients, you must tell your doctor before treatment. Rejuran restores a damaged barrier by injecting polynucleotides into the dermis to induce cell regeneration. It tends to be the most painful of the three treatments, and the treated area can appear swollen and bumpy — a texture known as "embossing" — for 2–3 days. If you have a photoshoot or event coming up, you'll need to plan your schedule around this downtime. (See the "Considerations" section below for information on pregnancy, breastfeeding, and medications.)

Juvelook: The Collagen Builder

If you're pregnant or breastfeeding, taking any medications, or have a history of allergies, you must disclose this during the consultation before treatment — see the "Considerations" section below for details.

Juvelook's PDLLA is a biodegradable polymer that slowly breaks down in the body while stimulating collagen production. Like planting a seed, collagen builds up gradually over time — so while you may feel an immediate boost in hydration right after treatment, actual improvement in pores and scars doesn't show up until 2–4 weeks later, with full effects confirmed only after 4–8 weeks. Swelling lasts about 24 hours, shorter than with Rejuran.

NCTF 135HA (the "Chanel Injection"): Fast Hydration and Glow

If you're pregnant or breastfeeding, taking any medications, or have a history of allergies, you must disclose this during the consultation before treatment — see the "Considerations" section below for details.

Non-crosslinked hyaluronic acid delivers hydration and absorbs quickly, rather than adding volume the way a filler does. Combined with vitamins, minerals, and amino acids, it provides immediate nourishment to skin cells, noticeably improving glow and hydration within 3–7 days. That said, it's worth knowing upfront that this treatment doesn't fundamentally change structural issues like pores or scarring — it's more of a conditioning treatment.

Why Korean Clinics Combine All Three

Korean clinics often apply all three treatments to different areas of the face at once. Rejuran is typically used on thin, easily damaged areas like around the eyes, Juvelook on the cheeks where pores and scarring are most visible, and NCTF 135HA across the whole face for an immediate boost in tone and glow.

There are broadly two approaches. The first is doing all three treatments in different areas during a single visit, which works even with a short stay. The second is a schedule counted backward from a specific event, like a wedding: Juvelook 8 weeks before, Rejuran 2 weeks before, and NCTF 135HA 1 week before the event, for a total timeline of around two months. Which approach fits you is decided during the consultation, based on how much time you have and how much improvement you're hoping for.

Considerations: Pain, Side Effects, Downtime, and Who Should Avoid It

Know the risks and precautions before you book.

🚨 When to Contact Your Clinic Immediately

Contact a medical facility right away if you experience severe pain, fever, or pus at the injection site, or symptoms suggesting an allergic reaction such as difficulty breathing or widespread hives. Ordinary swelling, redness, or embossing can be checked at your scheduled follow-up appointment.

You must disclose the following during the consultation before treatment: allergies (particularly the possibility of fish allergies related to salmon-derived ingredients), any medications you're currently taking, whether you're pregnant or breastfeeding, and any skin conditions or recent cosmetic procedures. Because all three treatments are injections, individual responses vary, and safety cannot be assumed without prior screening.

Comparing Pain and Downtime by Treatment

Rejuran has the highest pain and downtime (2–3 days of swelling), Juvelook is moderate (about 24 hours of swelling), and NCTF 135HA has the least (downtime under 1 day). However, shorter downtime doesn't mean greater structural improvement, and pain tolerance varies from person to person.

Pre-Screening: Allergies, Pregnancy, Breastfeeding, and Medications

There is some information suggesting that salmon-derived PN is generally well tolerated even in patients with fish allergies, but this varies by individual case and must always be confirmed in advance with a board-certified dermatologist. Whether you can undergo treatment may change if you're pregnant or breastfeeding, or taking certain medications (such as blood thinners) — don't make this determination on your own, and confirm it during the consultation.

When This Approach Isn't Right for You

If your schedule is tight — for example, a photoshoot the next day — and you can't accommodate 2–3 days of swelling afterward, Rejuran may not be the right fit. If your stay is too short to expect noticeable pore or scar improvement within 8 weeks, Juvelook alone may not be suitable. If loss of skin elasticity is your main concern, it may also be worth comparing energy-based lifting options instead of skin boosters.

👉 Wondering about non-injection options for skin laxity? Compare Ulthera, Thermage, and InMode lifting treatments in Korea!

If You're Getting It Done in Korea: Cost, Time, Visits, and Recovery

Typical costs, timing, and recovery for each treatment in Korea.

Treatment	Reference Price	Treatment Time	Downtime	Duration of Effect
Rejuran 2cc	₩280,000~	approx. 40 minutes–1 hour	2–3 days	6 months–1 year
Rejuran Eye 1cc	₩200,000~	approx. 40 minutes–1 hour	2–3 days	6 months–1 year
Rejuveluk (Rejuran + Juvelook combo)	₩466,000~	approx. 40 minutes–1 hour	2–3 days	6 months
Juvelook Skin 1cc	₩86,000~	approx. 40 minutes–1 hour	about 24 hours	6 months–1 year (after completing 3 sessions)
NCTF 135HA	~₩350,000	approx. 40 minutes–1 hour	under 1 day	6 months or more (after completing 4–5 sessions)

*The number of sessions and intervals between them should be reconfirmed during the consultation.

💡 One Visit vs. Multiple Visits

Combining treatments across different areas is possible even with a short stay, but an event-based, counted-backward schedule — Juvelook, then Rejuran, then NCTF — takes about two months, requiring multiple visits or an extended stay. Whichever approach you choose, it's essential to book only after a consultation at a vetted clinic with a board-certified dermatologist on staff. Whether a clinic is genuinely "vetted" should be judged not by marketing claims but by directly checking the medical staff's board certification, treatment experience, and how they respond if an adverse reaction occurs.

What Affects the Cost

Price varies depending on the number of areas treated, the amount used in cc, and whether it's a single session or a course package. When comparing quotes, be sure to check whether the prices in the table above are per session or for a full package.

Booking, Numbing, and Aftercare

The consultation and first treatment are often done on the same day; numbing cream is applied, and treatment begins once it takes effect after about 20 minutes. For 24 hours after treatment, it's recommended to avoid sun exposure, makeup, strenuous exercise, alcohol, saunas, and air travel.

❓ Frequently Asked Questions (FAQ)

Q: Can I get all three treatments in one visit?

Yes. Korean clinics often combine all three treatments in a single visit, applying each to different areas of the face.

Number of visits: One visit is possible when combining treatments across different areas
The combination order is decided during the consultation based on your skin condition and pain tolerance
Preparation: A prior consultation and disclosure of allergies and medications are required

Q: Are there cases where I shouldn't get these treatments?

Yes. Suitability depends on allergies, current medications, skin conditions, and whether you're pregnant or breastfeeding, and this is confirmed individually during the consultation.

Preparation: Disclose allergies, current medications, previous treatment history, and pregnancy/breastfeeding status in advance
The relationship between the salmon-derived ingredient (Rejuran) and fish allergies must always be reconfirmed during the consultation

Q: If I have a wedding coming up, when should I start treatment?

You should start by counting backward from the treatment that takes the longest — the typical order is Juvelook (8 weeks before) → Rejuran (2 weeks before) → NCTF 135HA (1 week before).

Time required: The full schedule takes around two months
If you're traveling from abroad, it's worth asking about the single-visit combination option during your consultation
Number of visits: A counted-backward schedule requires multiple visits or an extended stay

Q: Which treatment is most effective for acne scars?

Juvelook, which stimulates collagen production, is generally considered first for improving enlarged pores and acne scars.

Time required: Noticeable effects are felt starting 2–4 weeks after treatment, with full effects at 4–8 weeks
Whether to combine it with Rejuran is determined by your dermatologist during the consultation, based on scar depth and skin condition
How it works: PDLLA breaks down slowly while stimulating collagen production

Q: How much do these treatments cost in Korea, and how many sessions do I need?

Rejuran and Juvelook prices by area and volume are published, but the exact number of sessions, intervals, and NCTF pricing need to be confirmed during the consultation.

Cost: Rejuran 2cc ₩280,000~, Juvelook Skin 1cc ₩86,000~, Rejuveluk combo ₩466,000~
NCTF price: about ~₩350,000 per session
Number of visits/interval: roughly once every 4 weeks
When comparing quotes, check whether it's per session or a full course, and how many areas are treated

Next Steps

Planning a Consultation with SafeDoc

Which of the three treatments you get, and in what order, ultimately depends on how much time you have left and your skin condition. During the consultation, disclose any allergies, medications, and pregnancy status first, then discuss which approach fits your length of stay — a single-visit combination or a counted-backward schedule. If you'd like to compare other dermatology treatments beyond Rejuran, Juvelook, and NCTF, you can browse the full list of options at SafeDoc partner hospitals' dermatology treatments. Whichever clinic you choose, the single most important first step is verifying the doctor's board certification and treatment experience before booking.

Rejuran vs. Juvelook vs. Chanel Injection: The Ultimate Korean Skin Booster Guide 2026